The disease remains the third most frequent cause of worldwide cancer related death.
- A diet low in fruits and vegetables
- Family history of stomach cancer
- Germline mutation in the E-cadherin gene (CDH1)
- Mutation of TP53 gene
- Ingestion of high concentrations of nitrates found in dried,smoked, and salted foods-The nitrates are thought to be converted to carcinogenic nitrites by bacteria. Such bacteria may be introduced exogenously through the ingestion of partially decayed foods.
- Bacteria such as H. pylori may also contribute to this effect by causing chronic inflammatory atrophic gastritis, loss of gastric acidity, and bacterial growth in the stomach.
- Loss of acidity may occur when acid-producing cells of the gastric antrum have been removed surgically to control benign peptic ulcer disease or when achlorhydria, atrophic gastritis.
1.ORGANOPHOSPHORUS POISON(OP POISON)-Malathoin, Tetron, Parathion,Chlorthoin,Diazion(Tik 20)
2.ORGANO CHLORINES-DDT,Aldrin,Endrin,Endosulfan,Benzene Hexa Chloride
- Stomach pain
- Persistent vomiting
- Postprandial fullness to a severe, steady pain
- Unintentional weight loss
- Feeling bloated after eating
- Severe, persistent heartburn
- Severe indigestion that is always present
- Unexplained, persistent nausea
- Early satiety(Feeling full after eating small amounts of food)
- Bloody vomiting(haematemesis)
About 85% of stomach cancers are adenocarcinomas, with 15% due to lymphomas, gastrointestinal stromal tumors (GISTs), and leiomyosarcomas.
Gastric adenocarcinomas may be subdivided into two pathologically defined categories:
1.A DIFFUSE TYPE, in which cell cohesion is absent, so that individual cells infiltrate and thicken the stomach wall without forming a discrete mass
2.AN INTESTINAL TYPE, characterized by cohesive neoplastic cells that form glandlike tubular structures.
The diffuse carcinomas occur more often in younger patients, develop throughout the stomach (including the cardia), result in a loss of distensibility of the gastric wall (so-called linitis plastica, or “leather bottle” appearance), and carry a poorer prognosis. Diffuse cancers have defective intercellular adhesion, mainly as a consequence of loss of expression of E-cadherin.
Intestinal-type lesions are frequently ulcerative, more commonly appear in the antrum and lesser curvature of the stomach, and are often preceded by a prolonged precancerous process, often initiated by H. pylori infection.
- Avoid chemical pesticides, chemical fertilizer for farming
- Avoid herbicides
- Avoid weedicides
- Avoid rodenticide
- Eat organic fruits, vegetable
- Regular excersise
- Avoid smoking
- Eating foods high in fiber
- Drinking an adequate amount of fluids
- Avoid alcohol
- Avoid tobacco
- UPPER GI ENDOSCOPY
- CT ABDOMEN