SYSTEMIC LUPUS ERYTHEMATOSUS Systemic lupus erythematosus (SLE) is an autoimmune disease in which organs and cells undergo damage initially mediated by tissue-binding autoantibodies and immune complexes. CAUSES Tobacco smoking Drinking alcohol Exposure to crystalline silica e.g., inhalation of soap powder dust Soil in farming activities due use of pesticides, artificial fertilizer Genetic susceptibility Autoimmunity-inducing activation