HERPES SIMPLEX VIRUS INFECTIONS DEFINITION Herpes simplex viruses (HSV-1, HSV-2; Herpesvirus hominis) produce a variety of infections involving mucocutaneous surfaces, the central nervous system (CNS), and visceral organs. RISK FACTOR Oral sex Commercial sex worker Cigarette smoking Sex during menses Intrauterine device Early age of sexual intercourse New or multiple sexual partners Women Sexual activity